Sesame Street features humans and non-human muppets living together in peace, respecting eachother's ethnic diversity. Most aspects of adult life are seen on the show including birth (Maria has a baby), death (Mr. Hooper dies), homosexuality (Bert and Ernie who in reality are just roommates, though some claim that they have a "sinful" relationship), disability (Linda was deaf... also a muppet in a wheelchair), Obsessive Compulsive disorder (The Count needs to count everything), poverty and eccentricity (Oscar the Grouch lives in a trashcan and is mean to everyone).

Sesame Street also teaches a variety of languages. In the United States, the show is predominantly English wish Spanish segments intermixed. In Canada, the Spanish segments are replaced with French segments.