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#87 HOT-2
2,5-DIMETHOXY-4-ETHYLTHIO-N-HYDROXYPHENETHYLAMINE
SYNTHESIS: A
solution of 5.50 g
2,5-dimethoxy-4-ethylthio-beta-nitrostyrene (see under
2C-T-2 for its
preparation) was made in 80 mL boiling
anhydrous THF. On cooling,
there was some separation of a fine
crystalline phase, which was kept
dispersed by continuous stirring. Under an inert
atmosphere there was
added 3.5 mL of a 10 M
borane dimethylsulfide complex, followed by 0.5
g
sodium borohydride as a solid. There was a slight exothermic
response, and the color slowly faded. Stirring was continued for a
week. There was then added 40 mL H2O and 20 mL concentrated HCl, and
the reaction mixture heated on the steam bath for 15 minutes, with the
THF at reflux. After cooling again to room tem
perature, all was
poured into 1 L H2O and washed with 3x75 mL
CH2Cl2, which removed all
of the color but little of the product. The aqueous
phase was made
basic with 25%
NaOH, and extracted with 3x75 mL
CH2Cl2. The extracts
were pooled and the
solvent removed under vacuum to give a residue of
3.88 g of an amber oil. This was
dissolved in 30 mL IPA, acidified
with concentrated HCL to a bright red on universal
pH paper, and then
diluted with 200 mL
anhydrous Et2O. After a short period of time,
crystals started to form. These were removed by filtration, washed
with
Et2O, and air dried to constant weight. Thus was obtained 2.86 g
2,5-dimethoxy-4-
ethylthio-N-hydroxy
phenethylamine hydrochloride
(HOT-2) as off-white
crystals, with a melting point of 122 °C with
decomposition. Anal. (
C12H20ClNO3 S) H; C: calcd, 49.05; found,
50.15, 49.90.
DOSAGE: 10 - 18 mg.
DURATION: 6 - 10 h.
QUALITATIVE COMMENTS: (with 12 mg) Tastes OK. Some activity noticed
in 30 minutes. Very smooth rise with no body load for next two hours.
At that time I noted some visuals. Very pleasant. The bright spots
in the painting over the fireplace seemed to be moving backwards (as
if the clouds were moving in the painting). Upon concentrating on any
item, there was perceptual movement with a little flowing aspect. The
visuals were never all that strong, but could not be turned off during
the peak. At hour three there was still some shimmering, and it was
hard to focus when reading. Additionally, there was difficulty
concentrating (some mental confusion). The material seemed to allow
erotic actions; there was no problem about obtaining an
erection. I
ate very well, some crazy dips, as well as a fabulous cake. A very
gentle down trend and I became close to baseline by 6 or 7 PM. I had
no trouble driving. The dosage was good for me. I did not want more
or less.
(with 12 mg) Comes on smoothly, nicely. In 40 minutes I feel nice
euphoria, feel home again. Then I begin to get uncomfortable
feelings. Gets more and more uncomfortable, feel I am sitting on a
big problem. Blood pressure, pulse, go up considerably. Have hard
time communicating, lie down for a while, get insight that most
important thing for me to do is learn to listen, pay attention to what
is going on. I do this the rest of the day, at first with
considerable difficulty, then easier and easier. Discomfort stays
with me for several hours, and although I get more comfortable towards
the end of the day, I am never animated or
euphoric. I feel very
humbled, that I have a great deal to work out in my life. The next
day I find myself very strong and empowered. I see that all I have to
do is let things be as they are! This feels marvelous, and a whole
new way to be--much more relaxed, accepting, being in the moment. No
more axes to grind. I can be free.
(with 18 mg) I found myself with complete energy. I was completely
centered with an absolute minimum of the dark edges that so often
appear as components of these experiences. The ease of talking was
remarkable. There was some blood-pressure run-up in the early part of
the day, but that quickly returned to normal. I would repeat without
hesitation.
EXTENSIONS AND COMMENTARY: Again, a case of where the potency range of
the "hot," or
hydroxylated compound (HOT-2, 10 to 18 milligrams) is
very similar to that of the non-
hydroxylated prototype (
2C-T-2, 12-25
milligrams). It seems to be a well tolerated, and generally pleasant
material, with a mixture of sensory as well as insightful aspects.
Something for everyone.
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